Serotonin syndrome
Recent start or dose increase of a serotonergic agent (SSRI, SNRI, MAOI), often in combination.
How it presents
autonomic instability, hyperthermia, clonus, hyperreflexia, agitation, tremor, diarrhea
Tell it apart from
- Neuroleptic malignant syndrome
- Malignant hyperthermia
Treatment reasoning
Stop the serotonergic agent; supportive care, cooling, benzodiazepines for agitation; cyproheptadine in severe cases.