Neuroleptic malignant syndrome
After recent antipsychotic (esp. first-generation high-potency) initiation or dose increase.
How it presents
fevers, severe muscle rigidity, altered mental status, autonomic instability, elevated CK
Tell it apart from
- Serotonin syndrome
- Malignant hyperthermia
- Catatonia
Treatment reasoning
Stop the antipsychotic; supportive care, cooling, hydration; dantrolene and/or bromocriptine in severe cases.