Major depressive disorder
Two weeks of depressed mood or anhedonia plus additional symptoms causing impairment.
How it presents
depressed mood, anhedonia, sleep/appetite change, psychomotor change, fatigue, worthlessness/guilt, poor concentration, thoughts of death; ≥2 weeks; no manic/hypomanic history
Tell it apart from
- Persistent depressive disorder (dysthymia)
- Bipolar depression
- Bereavement
- Adjustment disorder
Treatment reasoning
SSRI/SNRI first-line, CBT/behavioral activation; combined for moderate-severe; suicide risk assessment first.